Quick Search:       Advanced Search
High-quality draft genome sequence of Streptomyces agglomeratus 5-1-8 with strong anti-MRSA ability, isolated from the frozen soil of Tibet in China
Received:October 19, 2016  Revised:January 13, 2017  Click here to download the full text
Citation of this paper:XiMing Chen,Ling Zhang,HaiLi Sun,ShuYan Li,SiJing Chang,QingFeng Zhang,BingLin Zhang,Tuo Chen,GuangXiu Liu,Paul Dyson,2017.High-quality draft genome sequence of Streptomyces agglomeratus 5-1-8 with strong anti-MRSA ability, isolated from the frozen soil of Tibet in China.Sciences in Cold and Arid Regions,9(5):503~510.
Hits: 29
Download times: 46
Author NameAffiliationE-mail
XiMing Chen Key Laboratory of Desert and Desertification, Northwest Institute of Eco-Environment and Resources, Chinese Academy of Sciences, Lanzhou, Gansu 730000, China;Key Laboratory of Extreme Environmental Microbial Resources and Engineering of Gansu Province, Lanzhou, Gansu 730000, China  
Ling Zhang Xinjiang Institute of Ecology and Geography, Chinese Academy of Science, Urumqi, Xinjiang 830011, China  
HaiLi Sun School of Chemistry and Environment Science, Lanzhou City University;Lanzhou, Gansu 730000, China  
ShuYan Li College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, Gansu 730000, China  
SiJing Chang Key Laboratory of Desert and Desertification, Northwest Institute of Eco-Environment and Resources, Chinese Academy of Sciences, Lanzhou, Gansu 730000, China;Key Laboratory of Extreme Environmental Microbial Resources and Engineering of Gansu Province, Lanzhou, Gansu 730000, China liugx@lzb.ac.cn 
QingFeng Zhang School of Life Sciences, Lanzhou University, Lanzhou, Gansu 730000, China  
BingLin Zhang Key Laboratory of Desert and Desertification, Northwest Institute of Eco-Environment and Resources, Chinese Academy of Sciences, Lanzhou, Gansu 730000, China;Key Laboratory of Extreme Environmental Microbial Resources and Engineering of Gansu Province, Lanzhou, Gansu 730000, China  
Tuo Chen Key Laboratory of Desert and Desertification, Northwest Institute of Eco-Environment and Resources, Chinese Academy of Sciences, Lanzhou, Gansu 730000, China;Key Laboratory of Extreme Environmental Microbial Resources and Engineering of Gansu Province, Lanzhou, Gansu 730000, China  
GuangXiu Liu Key Laboratory of Desert and Desertification, Northwest Institute of Eco-Environment and Resources, Chinese Academy of Sciences, Lanzhou, Gansu 730000, China;Key Laboratory of Extreme Environmental Microbial Resources and Engineering of Gansu Province, Lanzhou, Gansu 730000, China  
Paul Dyson Institute of Life Science, College of Medicine, Swansea University, Singleton Park, Swansea SA2 8PP, UK  
基金项目:This study was supported by the National Natural Science Foundation of China (Grant No. 31400437), the international cooperation program of Gansu (1504WKCA097), the application transformation foundation of CAS (HHS-CGZH-16-02), and UK BBSRC China Partnering Grant (BB/J020419/1).
 
Abstract:Streptomyces agglomeratus 5-1-8 with strong anti methicillin-resistant Staphylococcus aureus (MRSA) ability, isolated from the frozen soil of Tibet in China, has a strong ability to kill the multi-drugs-resistant MRSA. To identify the second-ary metabolism ability of this strain, we describe here the phenotypic characteristics of this strain, along with its high-quality draft genome sequence, its annotation, and analysis. The 7.1M draft genome encodes 6,284 putative open reading frames (ORFs), of which 4,416 ORFs were assigned with clusters of orthologous genes (COG) categories. Also, 65 tRNA genes and 24 rRNA operons were identified. The genome contains 12 gene clusters involved in antibiotics production and 1 gene cluster involved in anticancer-compounds production; 4 gene clusters belong to polyketides and nonribosomal peptides, 1 gene cluster belong to the butyrolactone, 4 gene clusters belong to the bacteriocin or lantipeptide, and 3 gene clusters belong to the others. This genome-sequence data will facilitate efforts to probe the potential of new antibiotics to kill multi-drugs-resistant MRSA.
keywords:Streptomyces  antibiotic  multi-drugs-resistant MRSA  genome  gene cluster
HTML  View Full Text  View/Add Comment  Download reader